Ameliorative potentials of methanol leaf extract of Anthocleista vogelli on mercury chloride-induced neurotoxicity
1,3*Egba, Simeon Ikechukwu; 2Okonkwo, Chibuzor Onyinye; 3Kalu, Uguru Grace 3Paul Promise, 1Chibuike, Sampson Nzubechi L, 4Egbachukwu Blessing Ifeoma 1Alum Esther Ugo and 1Ugwu Okechukwu Paul-Chima
1Department of Biochemistry, Research and Extension, Kampala International University, Uganda
2Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Cross Rivers State, Nigeria.
3Department of Biochemistry, Michael Okpara University of Agriculture, Umudike Abia State, Nigeria.
4Faculty Veterinary Medicine, University of Nigeria, Nsukka, Nigeria
Corresponding Author:Dr Simeon Ikechukwu Egba; +2348037750598, Simeon.egba@kiu.ac.ug, 0000-0002-8442-8869
ABSTRACT
In this work, the effects of A. vogelli leaf extract on a few neurotoxicity indicators in Wistar rats were examined. Group 1 consisted of a normal control group, Group 2 of mercury (II) chloride, Group 3 of mercury (II) chloride + Diazepam 5 mg/kg, and Group 4 of mercury (II) chloride + plant extract 400 mg/kg bw. The sixteen (16) male rats were divided into these four groups at random. Animals were slaughtered and medications and extracts were administered for 21 days. Cerebellum and cerebrum brain samples were obtained and examined. Using accepted procedures, assays for acetylcholinesterase, alpha-tocopherol, and adenine deaminase were conducted. The acetylcholinesterase activity, vitamin E concentration, and adenine deaminase activity in the untreated groups were significantly (p≤0.05) higher than in the control group. Additionally, it was noted that both the plant extract and the usual medication, diazepam, showed significantly higher levels of vitamin E and adenine deaminase activity (p≤0.05) accompanied with lower acetycholinesterase activity. This suggests that the plant extract may have the potential to be a neuroprotective agent and could be used to treat neurotoxicity and other related disorders.
Keywords: Neurotoxicity, acetylcholinesterase, alpha-tocopherol, adenine deaminase, Anthocleista vogelli.
CITE AS: Egba, Simeon Ikechukwu; Okonkwo, Chibuzor Onyinye; Kalu, Uguru Grace Paul Promise, Chibuike, Sampson Nzubechi L, Egbachukwu Blessing Ifeoma, Alum Esther Ugo and Ugwu Okechukwu Paul-Chima (2024). Ameliorative potentials of methanol leaf extract of Anthocleista vogelli on mercury chloride induced neurotoxicity. INOSR Experimental Sciences 13(2):15-22. https://doi.org/10.59298/INOSRES/2024/1321522.000