A Study on the Antioxidant Activities of Chrysophyllum Albidum on Testosterone-Induced Benign Prostatic Hyperplasia in Wistar Rat
1Egwuatu Anthony Ifeanyi; 2Ugwu Valentine Ifebuchechukwu and 3Ezeugwu Lilian Nnenna
1Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, Enugu State University of Science and Technology, Enugu, Nigeria.
2Department of Anatomy, Faculty of Basic Medical Sciences, State University of Medical and Applied Sciences, SUMAS, Igbo-Eno Enugu State, Nigeria.
3Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, Maduka University, Ekwegbe, Enugu State, Nigeria.
Corresponding author: Ugwu Valentine Ifebuchechukwu (valentineugwu66@gmail.com, valentine.ugwu@sumas.edu.ng +2348136236747)
ABSTRACT
Background: The study was designed to evaluate the antioxidant effect of Chrysophyllum albidum on testosterone-induced benign prostatic hyperplasia of Wistar rat.
Materials and Methods: Twenty-five Wistar rats were randomly selected into five groups. Group one, control; group two, administered with 25 mg/kg body weight of testosterone propionate intraperitoneally for ten days, while, groups three and four were administered 25 mg/kg of testosterone propionate followed by 200 mg/kg and 400 mg/kg of Chrysophyllum abidum for ten days. Group five rats were administered 25 mg/kg of testosterone propionate followed by 25 mg/kg of finasteride. The animals were sacrificed on the 11th day and the histoarchitecture of prostate gland and the biochemical parameters such as Superoxide dismutase (SOD), Malondialdehyde (MDA), Dihydrotestosterone (DHT) and caspase 3 were analyzed.
Results: The SOD had significant high value in group one and three compared with other groups. The MDA increased in group 2 and 4 compared to all other groups but the increment was not statistically significant. The DHT value for group 2 differed significantly from that of groups 1,4 and 5, while caspase 3 had no significant difference across the groups. Histologically, the treatments groups showed no tumoral infiltration in the surrounding stroma cells and the presence of mild dysplastic focal lesion in the epithelium of the prostate were no longer detected.
Conclusion: From the study, administration of the Chrysophyllum albidum extract in high dose had more positives effect on the activities of SOD, MDA and caspase 3 compared to the low dose in benign prostatic hyperplasia. Therefore, more studies are encouraged to investigate the long-term efficacy and safety of Chrysophyllum albidum extract as a possible natural alternative for the treatment of prostatic hyperplasia.
Keywords: Chrysophyllum albidum, Benign Prostatic Hyperplasia, Histoarchitecture, Superoxide dismutase, Malondialdehyde, Dihydrotestosterone.
CITE AS: Egwuatu Anthony Ifeanyi; Ugwu Valentine Ifebuchechukwu and Ezeugwu Lilian Nnenna (2026). A Study on the Antioxidant Activities of Chrysophyllum Albidum on Testosterone-Induced Benign Prostatic Hyperplasia in Wistar Rat. INOSR APPLIED SCIENCES 14(1):43-47. https://doi.org/10.59298/INOSRAS/2026/14.1.4347000