Microbiome Modulation in Obesity: Role of Prebiotics and Probiotics in Hyperlipidemia Control

Nalongo Bina K.

Faculty of Medicine Kampala International University Uganda

 ABSTRACT

Obesity is a major global health issue associated with metabolic disorders such as hyperlipidemia, which predisposes individuals to cardiovascular diseases. Emerging evidence highlights the critical role of the gut microbiome in modulating host metabolism, including lipid homeostasis, making it a potential target for therapeutic interventions. Prebiotics and probiotics, which can beneficially alter gut microbial composition and function, have gained considerable attention as non-pharmacological strategies to mitigate obesity-related hyperlipidemia. This review explores the mechanisms by which microbiome modulation through prebiotics and probiotics influences lipid metabolism and fat storage, focusing on their effects on dyslipidemia in obesity. It provides a detailed overview of the gut microbiota’s role in lipid absorption, bile acid metabolism, and the regulation of lipoprotein profiles. Furthermore, the review assesses clinical evidence supporting the efficacy of prebiotics and probiotics in managing hyperlipidemia and obesity-related metabolic disorders. The therapeutic potential of these microbiome-targeted interventions is evaluated, alongside future directions for integrating microbiome modulation into obesity and hyperlipidemia treatment regimens.

Keywords:  Obesity; Hyperlipidemia; Gut microbiome; Prebiotics; Probiotics

CITE AS: Nalongo Bina K. (2024). Microbiome Modulation in Obesity: Role of Prebiotics and Probiotics in Hyperlipidemia Control. INOSR Experimental Sciences 13(3):20-23. https://doi.org/10.59298/INOSRES/2024/1332023.000